HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Anisole | HCID 7519 | — |
| Reactant | 2-t-Butoxycarbonyl-9-allyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole | HCID 10859929 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Trifluoroacetate | HCID 84468 | — |
| Product | 9-Allyl-2,3,4,9-tetrahydro-pyrido[3,4-b]indole | HCID 11074712 | — |
Reaction Steps
Dichloromethane solution (20 ml) of 2-t-butoxycarbonyl-9-allyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (624 mg, 2.0 mmol) was mixed with anisole (2 ml) and trifluoroacetic acid (3 ml) and stirred at room temperature for 6 hours. By removing the solvent by evaporation under a reduced pressure, 9-allyl-2,3,4,9-tetrahydro-pyrido[3,4-b]indole was obtained as trifluoroacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06498251B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-dcd9cf738f994833b5af900ded003ec5 |
| Source note | uspto-grants-2002_12 |