反应详情

Ethanol and Raney nickel slurry (Aldrich) were added to 1-methyl-1H-benz[cd]indol-2-one (4.5 g, 25 mmol), and catalytic reduction was carried out under ordinary pressure. The reaction was completed when 1.15 L of hydrogen absorption was observed, and then Raney nickel was removed by filtration, the filtrate was concentrated and the resulting material was separated and purified by a silica gel column chromatography to obtain 3.8 g (20 mmol, 80% in yield) of the title compound.

1. customwhen 1.15 L of hydrogen absorption
2. customRaney nickel was removed by filtration
3. concentrationthe filtrate was concentrated
4. customthe resulting material was separated
5. custompurified by a silica gel column chromatography
6. customto obtain