Benz[cd]indol-2(1H)-one, 1-methyl- → Benz(cd)indol-2(1H)-one, 2a,3,4,5-tetrahydro-1-methyl-

Participants

Reaction Steps

Ethanol and Raney nickel slurry (Aldrich) were added to 1-methyl-1H-benz[cd]indol-2-one (4.5 g, 25 mmol), and catalytic reduction was carried out under ordinary pressure. The reaction was completed when 1.15 L of hydrogen absorption was observed, and then Raney nickel was removed by filtration, the filtrate was concentrated and the resulting material was separated and purified by a silica gel column chromatography to obtain 3.8 g (20 mmol, 80% in yield) of the title compound.

Provenance & Evidence