反应详情

5-t-Butoxycarbonyl-2-(morpholine-4-carbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine (610 mg, 1.7 mmol) was mixed with hydrochloric acid-saturated methanol and stirred at room temperature for two nights. The solvent was removed by evaporation from the reaction solution under a reduced pressure, and the residue was mixed with sodium hydroxide aqueous solution (1 N). The reaction product was extracted with ethyl acetate, and the organic layer was washed with saturated brine and dried with anhydrous magnesium sulfate. By evaporating the solvent from the organic layer under a reduced pressure, 270 mg (1.1 mmol, 63% in yield) of the title compound was obtained.

1. customThe solvent was removed by evaporation from the reaction solution under a reduced pressure
2. additionthe residue was mixed with sodium hydroxide aqueous solution (1 N)
3. extractionThe reaction product was extracted with ethyl acetate
4. washthe organic layer was washed with saturated brine
5. dry with materialdried with anhydrous magnesium sulfate
6. customBy evaporating the solvent from the organic layer