反应详情

3-Fluoro-2-methyl-benzoic acid methyl ester (4.3 g, 26 mmol), N-bromosuccinimide (5.0 g, 28 mmol) and AIBN (2,2′-azobisisobutyronitril) (420 mg, 2.6 mmol) were stirred at 80° C. for 10 hours in carbon tetrachloride (45 ml). The reaction solution was mixed with water and chloroform, washed with saturated sodium bicarbonate aqueous solution and saturated brine and then dried with anhydrous magnesium sulfate. The solvent was removed by evaporation from the extract under a reduced pressure, and the thus obtained material was separated and purified by a silica gel column chromatography to obtain 5.1 g (21 mmol, 81% in yield) of the title compound.

1. washwashed with saturated sodium bicarbonate aqueous solution and saturated brine
2. dry with materialdried with anhydrous magnesium sulfate
3. customThe solvent was removed by evaporation from the
4. extractionextract under a reduced pressure
5. customthe thus obtained material was separated
6. custompurified by a silica gel column chromatography
7. customto obtain