Pyridine → HCID 135488221, compound

HRID 2301204Notes

Reaction equation

HRID 2301204 reaction equation
C1(CN2CCC(C[CH2:15][C:16]3[C:20]4[CH:21]=[CH:22][C:23]5[NH:27][C:26](=[O:28])[CH2:25][C:24]=5[C:19]=4[O:18][N:17]=3)CC2)C=CC=CC=1.N1C=CC=CC=1>CN(C=O)C>[CH3:15][C:16]1[C:20]2[CH:21]=[CH:22][C:23]3[NH:27][C:26](=[O:28])[CH2:25][C:24]=3[C:19]=2[O:18][N:17]=1

Participants

4

Reactant 2

HCID 1049PyridineHCID 135517369HCID 135517369, compound

Product 1

HCID 135488221HCID 135488221, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The procedure described in Example 33d was followed with the oxime acetate obtained in step c (0.334 g, 1.35 mmol) and pyridine (0.55 mL, 6.75 mmol) in DMF (25 mL). After work-up, the residue was purified by silica gel flash chromatography (50→75% EtOAc-hexanes) to give the title compound (0.086 g, 34%) as a white solid.

Workup

  1. customAfter work-up, the residue was purified by silica gel flash chromatography (50→75% EtOAc-hexanes)

Sources & evidence

ORD record
ord-a2a700fad6c34375be32924d7622bdf0
Source dataset
uspto-grants-2002_12
Patent number
US06498255B2

Reaction notes

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