Hydrochloric Acid → HCID 178524522, compound

HRID 2301217Notes

Reaction equation

HRID 2301217 reaction equation
[N:1]1[C:8]([F:9])=[N:7][C:5](F)=[N:4][C:2]=1[F:3].[NH2:10][C:11]1[C:12]([OH:45])=[C:13]([N:21]=[N:22][C:23]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)=[N:24][NH:25][C:26]2[CH:31]=[C:30]([S:32]([OH:35])(=[O:34])=[O:33])[CH:29]=[CH:28][C:27]=2[C:36]([OH:38])=[O:37])[CH:14]=[C:15]([S:17]([OH:20])(=[O:19])=[O:18])[CH:16]=1.[OH-].[Na+].Cl>O>[F:9][C:8]1[N:1]=[C:2]([F:3])[N:4]=[C:5]([NH:10][C:11]2[C:12]([OH:45])=[C:13]([N:21]=[N:22][C:23]([C:39]3[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=3)=[N:24][NH:25][C:26]3[CH:31]=[C:30]([S:32]([OH:35])(=[O:33])=[O:34])[CH:29]=[CH:28][C:27]=3[C:36]([OH:38])=[O:37])[CH:14]=[C:15]([S:17]([OH:20])(=[O:19])=[O:18])[CH:16]=2)[N:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 12664Cyanuric fluorideHCID 14798Sodium Hydroxide2×HCID 178507976HCID 178507976, compound

Product 1

HCID 178524522HCID 178524522, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

9.65 parts of cyanuric fluoride are added to a neutral solution of 35.80 parts of the copper complex of 5-amino-3-[3-phenyl-5-(2-carboxy-5-sulfophenyl)-1-formazano]-4-hydroxybenzenesulfonic acid in 350 parts of water at 0 to 2° C. in the course of 10 minutes. During the addition the pH is kept at 5.8 to 6 with a 15% sodium hydroxide solution. After the addition the mixture is stirred for about 15 minutes, the pH is brought to 3.5 to 3.8 with 32% hydrochloric acid and the mixture is stirred again for about 15 minutes. The pH is then brought to about 5.8 to 6 with a 15% sodium hydroxide solution. A solution of 5-[4,6-difluoro-1,3,5-triazin-2-ylamino]-3-[3-phenyl-5-(2-carboxy-5-sulfophenyl)-1-formazano]-4-hydroxybenzenesulfonic acid is obtained.

Workup

  1. additionDuring the addition the pH
  2. additionAfter the addition the mixture
  3. stirringthe mixture is stirred again for about 15 minutes

Sources & evidence

ORD record
ord-4f21afd0c4fd43119fb2b19d23fa2645
Source dataset
uspto-grants-2002_12
Patent number
US06500247B1

Reaction notes

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