1,4-Dihydroxy-2,2,6,6-tetramethylpiperidine → HCID 3662321, compound

HRID 2301220Notes

Reaction equation

HRID 2301220 reaction equation
[OH:1][N:2]1[C:7]([CH3:9])([CH3:8])[CH2:6][CH:5]([OH:10])[CH2:4][C:3]1([CH3:12])[CH3:11].[CH2:13]([CH:15]1[O:17][CH2:16]1)Cl>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.[OH-].[Na+].C1(C)C=CC=CC=1>[OH:1][N:2]1[C:7]([CH3:8])([CH3:9])[CH2:6][CH:5]([O:10][CH2:13][CH:15]2[O:17][CH2:16]2)[CH2:4][C:3]1([CH3:12])[CH3:11]

Participants

6

Reactant 2

HCID 53951,4-Dihydroxy-2,2,6,6-tetramethylpiperidineHCID 7835Epichlorohydrin

Product 1

HCID 3662321HCID 3662321, compound

Reagents, catalysts & solvents 3

HCID 74236Tetrabutylammonium BromideCatalystHCID 1140TolueneSolventHCID 14798Sodium HydroxideSolvent

Procedure

A vigorously stirred two phase solution of 1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine, epichlorohydrin, tetrabutylammonium bromide in 50% aqueous sodium hydroxide and toluene is reacted together. The organic phase is dried over anhydrous magnesium sulfate and concentrated to yield the title compound as a low melting red solid after column chromatography.

Workup

  1. customis reacted together
  2. dry with materialThe organic phase is dried over anhydrous magnesium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-90e7b7ee943948a08862027580e044fd
Source dataset
uspto-grants-2002_12
Patent number
US06500303B1

Reaction notes

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