Benzoyl chloride, 3-nitro- → 3-Nitro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)benzamide

HRID 2301240Notes

Reaction equation

HRID 2301240 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7](Cl)=[O:8])([O-:3])=[O:2].NC1C=C(C=CC=1)C([NH:19][C:20]([CH2:26][CH3:27])([CH3:25])[C:21](=[O:24])[CH2:22][Cl:23])=O>[Pd]>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH:19][C:20]([CH2:26][CH3:27])([CH3:25])[C:21](=[O:24])[CH2:22][Cl:23])=[O:8])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 8495Benzoyl chloride, 3-nitro-HCID 183720013-amino-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)benzamide

Product 1

HCID 183720113-Nitro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)benzamide

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

3-Nitro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)benzamide was prepared by reaction of 3-nitrobenzoylchloride with VIII as in scheme A (above), then converted to 3-amino-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)benzamide by catalytic hydrogenation using palladium as the catalyst.

Sources & evidence

ORD record
ord-744720d810bc49e3b0cfe6af3a16f0de
Source dataset
uspto-grants-2002_12
Patent number
US06500405B1

Reaction notes

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