Triphenylphosphine → HCID 86585261, compound

HRID 2301246Notes

Reaction equation

HRID 2301246 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[CH2:5][CH2:6][Br:7].[C:12]1([P:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C=CC=CC=1>[Br-:7].[F:1][C:2]1[CH:3]=[C:4]([CH2:5][CH2:6][P+:18]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:8]=[CH:9][C:10]=1[F:11]

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 150200534-(2-Bromoethyl)-1,2-difluorobenzene

Product 1

HCID 86585261HCID 86585261, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 19.67 g (89 mmol) of 3,4-difluoro-phenethyl bromide, 28.07 g (107 mmol) of triphenyl phosphine and 134 ml of toluene was heated under reflux for 36 hrs. After cooling, the crystal was washed by decantation with toluene and dried in vacuo, while ice-cooling.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 36 hrs
  3. temperatureAfter cooling
  4. washthe crystal was washed by decantation with toluene
  5. customdried in vacuo, while ice-
  6. temperaturecooling

Sources & evidence

ORD record
ord-7c78d6c79f6d47a890b7c8a11ce406e0
Source dataset
uspto-grants-2002_12
Patent number
US06500503B2

Reaction notes

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