(s)-2-Allyloxycarbonylamino-3-(4-carbamimidoylphenyl)propionic acid ethyl ester hydrochloride → (S)-2-Allyloxycarbonylamino-3-(4-carbamimidoylphenyl)propionic Acid Hydrochloride

HRID 2301273Notes

Reaction equation

HRID 2301273 reaction equation
[ClH:1].C([O:4][C:5](=[O:24])[C@@H:6]([NH:17][C:18]([O:20][CH2:21][CH:22]=[CH2:23])=[O:19])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14](=[NH:16])[NH2:15])=[CH:10][CH:9]=1)C>Cl>[ClH:1].[CH2:21]([O:20][C:18]([NH:17][C@@H:6]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14](=[NH:15])[NH2:16])=[CH:10][CH:9]=1)[C:5]([OH:24])=[O:4])=[O:19])[CH:22]=[CH2:23]

Participants

3

Reactant 1

HCID 70002038(s)-2-Allyloxycarbonylamino-3-(4-carbamimidoylphenyl)propionic acid ethyl ester hydrochloride

Product 1

HCID 68613816(S)-2-Allyloxycarbonylamino-3-(4-carbamimidoylphenyl)propionic Acid Hydrochloride

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

17 g (0.048 mol) of (S)-2-allyloxycarbonylamino-3-(4-carbamimidoylphenyl)propionic acid ethyl ester hydrochloride were treated with 400 ml of half-concentrated hydrochloric acid for 3 h at RT. The solvent was evaporated (<30° C.) and the residue was stirred with ether. Yield=15 g (95%). MS=292.2 (M+1)+.

Workup

  1. customThe solvent was evaporated (<30° C.)

Sources & evidence

ORD record
ord-a3212dffc422424885fa07c604e674eb
Source dataset
uspto-grants-2002_12
Patent number
US06500803B1

Reaction notes

Loading…