Water → HCID 23668565, compound

HRID 2301303Notes

Reaction equation

HRID 2301303 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:26])[N:7]([S:13]([C:16]3[CH:17]=[C:18]([OH:25])[C:19](=[CH:23][CH:24]=3)[C:20]([OH:22])=[O:21])(=[O:15])=[O:14])[C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[OH-].[Na+:28].O>C1COCC1>[Na+:28].[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:26])[N:7]([S:13]([C:16]3[CH:17]=[C:18]([OH:25])[C:19](=[CH:23][CH:24]=3)[C:20]([O-:22])=[O:21])(=[O:15])=[O:14])[C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 9930656HCID 9930656, compound

Product 1

HCID 23668565HCID 23668565, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

50 mg (0.13 mmol) of Compound 15 was suspended in approximately 1 ml of THF, then 126 μl of 1N sodium hydroxide aqueous solution was added dropwise. The solution was confirmed to have become uniform, then 30 ml of water was added and the mixture freeze-dried to quantitatively obtain the above-identified compound in an amorphous state in an amount of 52 mg. Properties: colorless amorphous, PMR (δ ppm, CD3OD): 7.11 (1H, s), 7.19 (1H, d), 7.58 (1H, d), 7.63 (1H, s), 7.92 (1H, d), 8.03 (1H, d).

Workup

  1. customthe mixture freeze-dried
  2. customto quantitatively obtain the above-identified compound in an amorphous state in an amount of 52 mg

Sources & evidence

ORD record
ord-a2407ab4dc3242a68ed20db53e38a9bf
Source dataset
uspto-grants-2002_12
Patent number
US06500835B2

Reaction notes

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