反应详情

20 mg (59pmol) of the compound obtained in Example 23 was dissolved in 2 ml of methylenechloride, and the mixture was reacted with excess amount of boron tribromide (BBr3) at room temperature for 3 hours. The resulting product was concentrated. Then the produced solid was washed with methylenechloride and 10% methanol/methylenechloride, filtered, and dried to give 18 mg of the title compound in a yield of 93%.

1. concentrationThe resulting product was concentrated
2. washThen the produced solid was washed with methylenechloride and 10% methanol/methylenechloride
3. filtrationfiltered
4. customdried