HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → N-[2-(3,4-Dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 2-(benzo[1,3]dioxol-5-yl)-3-hydroxy-6-acetamido-4H-1-benzopyran-4-one | HCID 9949777 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[2-(3,4-Dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]acetamide | HCID 18372820 | 93,215,920% |
Reaction Steps
20 mg (59pmol) of the compound obtained in Example 23 was dissolved in 2 ml of methylenechloride, and the mixture was reacted with excess amount of boron tribromide (BBr3) at room temperature for 3 hours. The resulting product was concentrated. Then the produced solid was washed with methylenechloride and 10% methanol/methylenechloride, filtered, and dried to give 18 mg of the title compound in a yield of 93%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06500846B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-4b829a229d4f4b51a90c809765c10599 |
| Source note | uspto-grants-2002_12 |