Boron tribromide → HCID 18372613, compound

HRID 2301427Notes

Reaction equation

HRID 2301427 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([S:12]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)(=[O:14])=[O:13])[C:9]([O:23]C)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.B(Br)(Br)Br>>[Cl:1][C:2]1[CH:11]=[C:10]([S:12]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)(=[O:13])=[O:14])[C:9]([OH:23])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 18372489HCID 18372489, compound

Product 1

HCID 18372613HCID 18372613, compound

Procedure

The title compound is prepared from 5-chloro-N-(4-chlorophenyl)-8-methoxy-7-quinolinesulfonamide, which is the first title compound of Preparation 9, and 6 equivalents of BBr3 according to the procedure described in Example 18. Crystallization from Et2O/hexane/CH2Cl2 affords 0.015 g of the title compound as a red-brown solid.

Workup

  1. customCrystallization from Et2O/hexane/CH2Cl2

Sources & evidence

ORD record
ord-60aadbccc3f64c46beeca926c6f8b13c
Source dataset
uspto-grants-2002_12
Patent number
US06500842B1

Reaction notes

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