Boron tribromide → HCID 18372559, compound

HRID 2301428Notes

Reaction equation

HRID 2301428 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([S:12]([NH:15][CH2:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)(=[O:14])=[O:13])[C:9]([O:25]C)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.B(Br)(Br)[Br:28]>>[BrH:28].[Cl:1][C:2]1[CH:11]=[C:10]([S:12]([NH:15][CH2:16][CH2:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)(=[O:13])=[O:14])[C:9]([OH:25])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 18372710HCID 18372710, compound

Product 1

HCID 18372559HCID 18372559, compound

Procedure

The title compound is prepared from 5-chloro-8-methoxy-N-(3-phenylpropyl)-7-quinolinesulfonamide, which is the title compound of Preparation 11, and 6 equivalents of BBr3 according to the procedure described in Example 18. Crystallization from CHCl3/acetone/EtOH affords 0.063 g of the title compound as a red-brown solid.

Workup

  1. customCrystallization from CHCl3/acetone/EtOH

Sources & evidence

ORD record
ord-e1ca4ac2fac14a108f997656ad727abc
Source dataset
uspto-grants-2002_12
Patent number
US06500842B1

Reaction notes

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