Benzaldehyde → HCID 70162596, compound

HRID 2301439Notes

Reaction equation

HRID 2301439 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]([Br:12])[C:9]([O:13][CH3:14])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:15])=[N:7]2.[CH:16](=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CO>[Br:1][C:2]1[CH:11]=[C:10]([Br:12])[C:9]([O:13][CH3:14])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH:15]=[CH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[N:7]2

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 18372725HCID 18372725, compound

Product 1

HCID 70162596HCID 70162596, compoundYield 83.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 5,7-dibromo-2-methyl-8-methoxyquinoline (10.29 g) and benzaldehyde (15.84 g) is heated at reflux for 18 hrs. Upon cooling to room temperature, a precipitate forms. Methanol is added, and the reaction mixture is sonicated. The solid material is then collected by filtration. Crystallization from hot absolute ethanol yields 10.872 g of the title compound as a yellow solid.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 18 hrs
  3. customthe reaction mixture is sonicated
  4. filtrationThe solid material is then collected by filtration
  5. customCrystallization from hot absolute ethanol

Sources & evidence

ORD record
ord-759a67c607bc4cd9a9f82f1db507fc7d
Source dataset
uspto-grants-2002_12
Patent number
US06500842B1

Reaction notes

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