反应详情

温度

-78 °C

A suspension of 5-fluoro-8-hydroxy-7-quinolinesulfonyl chloride (0.150 g) in 2 mL of THF is cooled to −78° C. and treated with benzylamine (0.186 mL). The mixture is allowed to warm to 25° C. over several hours, then diluted with 50 μL of glacial acetic acid and 2 mL of distilled water. The oil which forms is crystallized by scratching, and the resulting suspension is stirred for one hour. The solid is filtered, washed with two 2 mL portions of distilled water and dried in a stream of air to give 0.121 g of the title compound as a solid.

1. temperatureto warm to 25° C. over several hours
2. customThe oil which forms is crystallized
3. filtrationThe solid is filtered
4. washwashed with two 2 mL portions of distilled water
5. customdried in a stream of air