Urea → HCID 9884431, compound

HRID 2301508Notes

Reaction equation

HRID 2301508 reaction equation
NC(N)=O.[NH2:5][C:6]1[C:7]([OH:17])=[C:8]([S:13]([NH2:16])(=[O:15])=[O:14])[C:9]([Cl:12])=[CH:10][CH:11]=1.[C:18]1([N:24]=[C:25]=[O:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([NH:5][C:25]([NH:24][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:26])=[C:7]([OH:17])[C:8]=1[S:13]([NH2:16])(=[O:15])=[O:14]

Participants

4

Reactant 3

HCID 1176UreaHCID 7672Phenyl isocyanateHCID 113680593-Amino-6-chloro-2-hydroxy-benzenesulfonamide

Product 1

HCID 9884431HCID 9884431, compoundYield 41%

Procedure

Following the general procedure for urea formation outlined in example 12, 3-amino-6-chloro-2-hydroxybenzenesulfonamide (40 mg, 0.18 mmol) and phenylisocyanate (32 mg, 0.27 mmol) were coupled to form the desired urea (25 mg, 41%). EI-MS (m/z) 340.3, 342.3 (M−).

Sources & evidence

ORD record
ord-7943da495c7a4e18b9498c5c2fee7b01
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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