Water → HCID 18373430, compound

HRID 2301512Notes

Reaction equation

HRID 2301512 reaction equation
[CH:1]([NH:4][S:5]([C:8]1[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-:17])=[O:16])[C:9]=1Cl)(=[O:7])=[O:6])([CH3:3])[CH3:2].[H-].[Na+].[OH2:21]>>[CH:1]([NH:4][S:5]([C:8]1[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-:17])=[O:16])[C:9]=1[OH:21])(=[O:7])=[O:6])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 18373477HCID 18373477, compound

Product 1

HCID 18373430HCID 18373430, compoundYield 57.2%

Procedure

Following the general hydrolysis procedure outlined in example 15, N-isopropyl-2,6-dichloro-3-nitrobenzenesulfonamide (1.3 g, 4.15 mmol), NaH (60%, 500 mg, 12.45 mmol) and water (89 mg, 4.98 mmol) were reacted to form the desired product (0.7 g, 57%). EI- MS m/z 293.5 (M-H)−.

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-8b6d9854db7947058eca2cbdbca9f3da
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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