Urea → HCID 11530829, compound

HRID 2301515Notes

Reaction equation

HRID 2301515 reaction equation
NC(N)=O.[NH2:5][C:6]1[C:7]([OH:17])=[C:8]([S:13]([NH2:16])(=[O:15])=[O:14])[C:9]([Cl:12])=[CH:10][CH:11]=1.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]=[C:27]=[O:28]>>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([NH:5][C:27]([NH:26][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[O:19][CH3:18])=[O:28])=[C:7]([OH:17])[C:8]=1[S:13]([NH2:16])(=[O:15])=[O:14]

Participants

4

Reactant 3

HCID 1176UreaHCID 69695Benzene, 1-isocyanato-2-methoxy-HCID 113680593-Amino-6-chloro-2-hydroxy-benzenesulfonamide

Product 1

HCID 11530829HCID 11530829, compoundYield 34.4%

Procedure

Following the general procedure for urea formation outlined in example 12, 3-amino-6-chloro-2-hydroxybenzenesulfonamide (40 mg, 0.18 mmol) and 2-methoxyphenylisocyanate (33 mg, 0.22 mmol) ) were coupled to form the desired urea (23 mg, 34%). EI-MS (m/z) 370.3, 372.1(M).

Sources & evidence

ORD record
ord-14a12cc5016f46d1927e158e195bfdf9
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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