HCID 18373447, compound → HCID 18373556, compound

HRID 2301526Notes

Reaction equation

HRID 2301526 reaction equation
[Cl:1][C:2]1[C:7]([S:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])=[C:6]([OH:17])[C:5]([N+:18]([O-])=O)=[CH:4][CH:3]=1.[H][H]>[Pd]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:18])=[C:6]([OH:17])[C:7]=1[S:8]([N:11]1[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1)(=[O:9])=[O:10]

Participants

4

Reactant 2

HCID 18373447HCID 18373447, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373556HCID 18373556, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, 6-chloro-2-hydroxy-1-(4-morpholinylsulfonyl)-3-nitrobenzene (210 mg, 0.65 mmol) was reduced with hydrogen and Pd/C (100 mg) to form the desired product (180 mg, 95%). 1H NMR (MeOD-d4): δ 6.28 (mn, 2H), 3.68 (t, 4H), 3.30 (t, 4H).

Sources & evidence

ORD record
ord-0306ec6f92c141a89d31fc243dc2e895
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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