Triethylamine → HCID 18373568, compound

HRID 2301528Notes

Reaction equation

HRID 2301528 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[NH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24].C(N(CC)CC)C>>[C:23]([O:22][C:21]([NH:20][CH2:19][CH2:18][CH2:17][NH:16][S:12]([C:3]1[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[Cl:1])(=[O:14])=[O:13])=[O:27])([CH3:26])([CH3:25])[CH3:24]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 2735700tert-Butyl (3-aminopropyl)carbamateHCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 18373568HCID 18373568, compoundYield 98%

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (1.0 g, 3.44 mmnol), t-butyl N-(3-aminopropyl)carbamate (0.60 mg, 3.44 mmol) and triethylamine(960 μL, 6.88 mmol) were reacted to form the desired product (1.44 g, 98%). EI-MS (m/z) 426.1, 428.1, 430.1 (M-H)−.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-3c7b7c3919ac4211b8e058e9add58d0e
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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