Water → HCID 18373436, compound

HRID 2301529Notes

Reaction equation

HRID 2301529 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][NH:12][S:13]([C:16]1[C:21]([Cl:22])=[CH:20][CH:19]=[C:18]([N+:23]([O-:25])=[O:24])[C:17]=1Cl)(=[O:15])=[O:14])=[O:7])([CH3:4])([CH3:3])[CH3:2].[H-].[Na+].[OH2:29]>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][NH:12][S:13]([C:16]1[C:21]([Cl:22])=[CH:20][CH:19]=[C:18]([N+:23]([O-:25])=[O:24])[C:17]=1[OH:29])(=[O:15])=[O:14])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 18373568HCID 18373568, compound

Product 1

HCID 18373436HCID 18373436, compoundYield 58.1%

Procedure

Following the general hydrolysis procedure outlined in example 15, N-[3-(tert-butoxycarbonylamino)propyl]-2,6-dichloro-3-nitrobenzenesulfonamide (450 mg, 1.05 mmol), 60% NaH (168 mg, 4.2 mmol) and water (21 μL, 1.15 mmol) were reacted to form the desired product (250 mg, 58%). EI-MS (m/z) 408.1, 410.1 (M-H)−.

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-9aa2f2ade0294b358a33afd4e09c7e97
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

Loading…