Triethylamine → HCID 18373510, compound

HRID 2301538Notes

Reaction equation

HRID 2301538 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[N:16]1([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.C(N(CC)CC)C>>[C:25]([O:24][C:22]([N:16]1[CH2:21][CH2:20][N:19]([S:12]([C:3]2[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=2[Cl:1])(=[O:14])=[O:13])[CH2:18][CH2:17]1)=[O:23])([CH3:28])([CH3:26])[CH3:27]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 18373510HCID 18373510, compoundYield 85.8%

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (500 mg, 1.72 mmol), tert-butyl 1-piperazinecarboxylate (320 mg, 1.72 mmol) and triethylamine (479 ,μL, 3.44 mmol) were reacted to form the desired product (650 mg, 84%). LC-MS (m/z) 440.2 (M+).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-496a315fc14541bd9a1c0720cfd0fadc
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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