Water → HCID 18373540, compound

HRID 2301539Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:22]([Cl:23])=[CH:21][CH:20]=[C:19]([N+:24]([O-:26])=[O:25])[C:18]=2Cl)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H-].[Na+].[OH2:30]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:22]([Cl:23])=[CH:21][CH:20]=[C:19]([N+:24]([O-:26])=[O:25])[C:18]=2[OH:30])(=[O:16])=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 3

HCID 962Water

HCID 24758Sodium hydride

HCID 18373510HCID 18373510, compound

Product 1

HCID 18373540HCID 18373540, compoundYield 32%

Procedure

Following the general hydrolysis procedure outlined in example 15, 1-[4-(tert-butoxycarbonyl)piperazin-1-yl]sulfonyl-2,6-dichloro-3-nitrobenzene (200 mg, 0.45 mmol), 60% NaH (54 mg, 1.35 mmol) and water (8μL, 0.45 mmol) were reacted to form the desired product (60 mg, 32%). EI-MS (m/z) 420.1, 422.1 (M+).

Workup

customthe general hydrolysis procedure
customwere reacted

Sources & evidence

ORD record: ord-423acdd05e104bef83f71c8f3536d19b
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06500863B1

Reaction notes

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