Urea → HCID 11692737, compound

HRID 2301543Notes

Reaction equation

HRID 2301543 reaction equation
NC(N)=O.[C:5]([O:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]([S:18]([C:21]2[C:22]([OH:29])=[C:23]([CH:25]=[CH:26][C:27]=2[Cl:28])[NH2:24])(=[O:20])=[O:19])[CH2:14][CH2:13]1)=[O:11])([CH3:8])([CH3:7])[CH3:6].[Cl:30][C:31]1[C:36]([Cl:37])=[CH:35][CH:34]=[CH:33][C:32]=1[N:38]=[C:39]=[O:40]>>[C:5]([O:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]([S:18]([C:21]2[C:22]([OH:29])=[C:23]([NH:24][C:39]([NH:38][C:32]3[CH:33]=[CH:34][CH:35]=[C:36]([Cl:37])[C:31]=3[Cl:30])=[O:40])[CH:25]=[CH:26][C:27]=2[Cl:28])(=[O:19])=[O:20])[CH2:14][CH2:13]1)=[O:11])([CH3:8])([CH3:6])[CH3:7]

Participants

4

Reactant 3

HCID 1176UreaHCID 330501,2-Dichloro-3-isocyanatobenzeneHCID 18373502HCID 18373502, compound

Product 1

HCID 11692737HCID 11692737, compoundYield 25%

Procedure

Following the general procedure for urea formation outlined in example 15, 3-[4-(tert- butoxycarbonyl)piperazin-1-yl]sulfonyl4-chloro-2-hydroxyaniline (110 mg, 0.28 mmol) and 2,3-dichlorophenylisocyanate (64 mg, 0.34 mmol) were coupled to form the desired urea (34 mg, 25%). EI-MS (m/z) 576.65, 578.65, 580.67 (M−).

Sources & evidence

ORD record
ord-921b8c55d5aa4b1ca9cc97d77b52d495
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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