Triethylamine → HCID 17927794, compound

HRID 2301545Notes

Reaction equation

HRID 2301545 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[CH3:16][S:17][CH2:18][CH2:19][CH2:20][NH2:21].C(N(CC)CC)C>>[CH3:16][S:17][CH2:18][CH2:19][CH2:20][NH:21][S:12]([C:3]1[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[Cl:1])(=[O:14])=[O:13]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 777433-(Methylthio)propylamineHCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 17927794HCID 17927794, compoundYield 83.8%

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6- dichloro-3-nitrobenzenesulfonyl chloride (2 g, 6.88 mmol), 3-(methylthio)propylamine (0.72 g, 6.88 mmol) and triethylamine (1.92 mL, 13.76 mmol) were reacted to form the desired product (2.07 g, 82%). 1H NMR (MeOD-d4): δ 7.93 (d, 1H), 7.79 (d, 1H), 3.16 (t, 2H), 2.47 (t, 2H), 2.00 (s, 3H), 1.76 (m, 2H).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-978e0d6899b34e63ae2975e4640d83d5
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

Loading…