Water → HCID 18373529, compound

HRID 2301546Notes

Reaction equation

HRID 2301546 reaction equation
[CH3:1][S:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[C:12]([N+:17]([O-:19])=[O:18])[C:11]=1Cl)(=[O:9])=[O:8].[H-].[Na+].[OH2:23]>>[CH3:1][S:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[C:12]([N+:17]([O-:19])=[O:18])[C:11]=1[OH:23])(=[O:9])=[O:8]

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 17927794HCID 17927794, compound

Product 1

HCID 18373529HCID 18373529, compoundYield 69%

Procedure

Following the general hydrolysis procedure outlined in example 15, N-(3-methylthiopropyl)-2,6-dichloro-3-nitrobenzenesulfonamide (1.0 g, 2.78 mmol), 60% NaH (330 mg, 8.13 mmol) and water (59 μL, 3.25 mmol) were reacted to form the desired product (650 mg, 69%). EI-MS (m/z) 339.86, 341.84 (M−).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-7d627a39c7584c7486aa46cfe96afc26
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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