Water → HCID 18373431, compound

HRID 2301552Notes

Reaction equation

HRID 2301552 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:20][CH2:21][O:22][CH3:23])[S:6]([C:9]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([N+:16]([O-:18])=[O:17])[C:10]=1Cl)(=[O:8])=[O:7].[H-].[Na+].[OH2:26]>>[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:20][CH2:21][O:22][CH3:23])[S:6]([C:9]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([N+:16]([O-:18])=[O:17])[C:10]=1[OH:26])(=[O:8])=[O:7]

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 18373476HCID 18373476, compound

Product 1

HCID 18373431HCID 18373431, compoundYield 55%

Procedure

Following the general hydrolysis procedure outlined in example 15, N,N-di-(2-methoxyethyl)-2,6-dichloro-3-nitrobenzenesulfonamide (800 mg, 2.07 mmol), 60% NaH (248 mg, 6.21 mmol) and water (45 μL, 2.48 mmol) were reacted to form the desired product (420 mg, 55%). EI-MS (m/z) 366.89, 368.81 (M−).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-877b07b79c2642eea6533dac53fc4f60
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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