Water → HCID 18373557, compound

HRID 2301558Notes

Reaction equation

HRID 2301558 reaction equation
[CH3:1][N:2]([CH3:20])[CH2:3][CH2:4][NH:5][S:6]([C:9]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([N+:16]([O-:18])=[O:17])[C:10]=1Cl)(=[O:8])=[O:7].[H-].[Na+].[OH2:23]>>[CH3:1][N:2]([CH3:20])[CH2:3][CH2:4][NH:5][S:6]([C:9]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([N+:16]([O-:18])=[O:17])[C:10]=1[OH:23])(=[O:8])=[O:7]

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 18373566HCID 18373566, compound

Product 1

HCID 18373557HCID 18373557, compound

Procedure

Following the general hydrolysis procedure outlined in example 15, crude N-[2-(dimethylamino)ethyl]-2,6-dichloro-3-nitrobenzenesulfonamide (480 mg), 60% NaH (168 mg, 4.2 mmol) and water (25 μL, 1.4 mmol) were reacted. The crude product (80 mg) was carried on to the next step without purification. EI-MS (m/z) 321.98, 323.96 (M−).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted
  3. customThe crude product (80 mg) was carried on to the next step without purification

Sources & evidence

ORD record
ord-905020c429774ca080debdd8688c9171
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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