Water → HCID 54535072, compound

HRID 2301560Notes

Reaction equation

HRID 2301560 reaction equation
[N:1]1([CH2:7][CH2:8][NH:9][S:10]([C:13]2[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([N+:20]([O-:22])=[O:21])[C:14]=2Cl)(=[O:12])=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[H-].[Na+].[OH2:26]>>[N:1]1([CH2:7][CH2:8][NH:9][S:10]([C:13]2[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([N+:20]([O-:22])=[O:21])[C:14]=2[OH:26])(=[O:12])=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 54395400HCID 54395400, compound

Product 1

HCID 54535072HCID 54535072, compoundYield 157.7%

Procedure

Following the general hydrolysis procedure outlined in example 15, N-[2-(morpholinyl)ethyl]-2,6-dichloro-3-nitrobenzenesulfonamide (400 mg, 1.04 mmol), 60% NaH (125 mg, 3.12 mmol) and water (23 μL, 1.25 mmol) were reacted to form the crude product (600 mg) which was carried onto the hydrogenation without purification. EI-MS (m/z) 363.95, 365.94 (M−).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-50efec8fae814752adced6e68b038d01
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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