Water → HCID 18373517, compound

HRID 2301563Notes

Reaction equation

HRID 2301563 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12]([N:15]1[CH2:20][CH2:19][S:18][CH2:17][CH2:16]1)(=[O:14])=[O:13].[H-].[Na+].[OH2:23]>>[Cl:11][C:4]1[C:3]([S:12]([N:15]2[CH2:20][CH2:19][S:18][CH2:17][CH2:16]2)(=[O:14])=[O:13])=[C:2]([OH:23])[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 18373505HCID 18373505, compound

Product 1

HCID 18373517HCID 18373517, compoundYield 33.5%

Procedure

Following the general hydrolysis procedure outlined in example 15, 2,6-dichloro-3-nitro-1-(4-thiomorpholinylsufonyl)benzene (1.04 g, 2.91 mmol), 60% NaH (349 mg, 8.73 mmol) and water (63 μL, 3.50 mmol) were reacted to form the desired product (330 mg, 33%). EI-MS (m/z) 336.89, 338.93 (M−).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-da6f55e1c6a549e5acb569c393e1f65b
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

Loading…