HCID 18373532, compound → HCID 18373537, compound

HRID 2301571Notes

Reaction equation

HRID 2301571 reaction equation
[Cl:1][C:2]1[C:7]([S:8]([N:11]2[CH2:16][CH2:15][S:14](=[O:17])[CH2:13][CH2:12]2)(=[O:10])=[O:9])=[C:6]([OH:18])[C:5]([N+:19]([O-])=O)=[CH:4][CH:3]=1.[H][H]>[Pd]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:19])=[C:6]([OH:18])[C:7]=1[S:8]([N:11]1[CH2:12][CH2:13][S:14](=[O:17])[CH2:15][CH2:16]1)(=[O:10])=[O:9]

Participants

4

Reactant 2

HCID 18373532HCID 18373532, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373537HCID 18373537, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, 6-chloro-2-hydroxy-3-nitro- 1-(1-oxidothiomorpholinosulfonyl)benzene (103 mg, 0.29mmol) was reduced with hydrogen and 10% Pd/C (59 mg) to form the desired product (89 mg, 95%). LC-MS (m/z) 325.0 (M+).

Sources & evidence

ORD record
ord-8970bcc9d7744a93be9d209d604faf67
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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