HCID 18373486, compound → HCID 18373528, compound

HRID 2301577Notes

Reaction equation

HRID 2301577 reaction equation
[N:1]1([S:5]([C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-])=O)[C:9]=2[OH:18])(=[O:7])=[O:6])[CH2:4][CH2:3][CH2:2]1.[H][H]>[Pd]>[N:1]1([S:5]([C:8]2[C:9]([OH:18])=[C:10]([CH:11]=[CH:12][C:13]=2[Cl:14])[NH2:15])(=[O:7])=[O:6])[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 18373486HCID 18373486, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373528HCID 18373528, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, 1-(azetidin-1-yl)sulfonyl-6-chloro-2-hydroxy-3-nitrobenzene (240 mg, 0.82 mmol) was reduced with hydrogen and 10% Pd/C (110 mg) to form the desired product (215 mg, 100%). 1H NMR (MeOD-d4): δ 6.91 (m, 2H), 4.01 (t, 4H), 2.23 (m, 2H).

Sources & evidence

ORD record
ord-b2782522d51043fca369d957bc883fa2
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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