HCID 18373507, compound → HCID 18373462, compound

HRID 2301582Notes

Reaction equation

HRID 2301582 reaction equation
[CH:1]1([NH:4][S:5]([C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-])=O)[C:9]=2[OH:18])(=[O:7])=[O:6])[CH2:3][CH2:2]1.[H][H]>[Pd]>[CH:1]1([NH:4][S:5]([C:8]2[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([NH2:15])[C:9]=2[OH:18])(=[O:7])=[O:6])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 18373507HCID 18373507, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373462HCID 18373462, compoundYield 99.3%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, N-cyclopropyl-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide (740 mg, 2.53 mmol) was reduced with hydrogen and 10% Pd/C (350 mg) to form the desired product (660 mg, 99%). 1H NMR (MeOD-d4): δ 6.83 (m, 2H), 2.20 (m, 1H), 0.56 (m, 4H).

Sources & evidence

ORD record
ord-9523187d02ff4fbd9b1f1cc0a68339ac
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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