HCID 18373450, compound → HCID 18373574, compound

HRID 2301587Notes

Reaction equation

HRID 2301587 reaction equation
[CH2:1]([NH:4][S:5]([C:8]1[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-])=O)[C:9]=1[OH:18])(=[O:7])=[O:6])[CH2:2][CH3:3].[H][H]>[Pd]>[CH2:1]([NH:4][S:5]([C:8]1[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([NH2:15])[C:9]=1[OH:18])(=[O:7])=[O:6])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 18373450HCID 18373450, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373574HCID 18373574, compoundYield 96.2%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, N-propyl-6chloro-2-hydroxy-3-nitrobenzenesulfonamide (650 mg, 2.2 mmol) was reduced with hydrogen and 10% Pd/C (320 mg) to form the desired product (560 mg, 96%). 1H NMR (MeOD-d4): δ 6.83 (m, 1H), 2.86 (t, 2H), 1.50 (m, 2H), 0.87 (t, 3H).

Sources & evidence

ORD record
ord-bf56b3731d324ceb99db5deead03467e
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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