Ethylamine → HCID 17927820, compound

HRID 2301591Notes

Reaction equation

HRID 2301591 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[CH2:16]([NH2:18])[CH3:17].C(N(CC)CC)C>>[CH2:16]([NH:18][S:12]([C:3]1[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[Cl:1])(=[O:14])=[O:13])[CH3:17]

Participants

4

Reactant 3

HCID 6341EthylamineHCID 8471TriethylamineHCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 17927820HCID 17927820, compoundYield 74.2%

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (800 mg, 2.75 mmol), ethylamine (4.13 mL, 8.26 mmol) and triethylamine(1.5 mL, 8.36 mmol) were reacted to form the desired product (610 mg, 74%). 1H NMR (MeOD-d4): δ 7.92 (d, 1H), 7.78 (d, 1H), 3.08 (q, 2H), 1.11 (t, 3H).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-8c6b2d77506e4e469fcd91f677ac281a
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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