HCID 18373485, compound → HCID 18373492, compound

HRID 2301593Notes

Reaction equation

HRID 2301593 reaction equation
[CH2:1]([NH:3][S:4]([C:7]1[C:12]([Cl:13])=[CH:11][CH:10]=[C:9]([N+:14]([O-])=O)[C:8]=1[OH:17])(=[O:6])=[O:5])[CH3:2].[H][H]>[Pd]>[CH2:1]([NH:3][S:4]([C:7]1[C:12]([Cl:13])=[CH:11][CH:10]=[C:9]([NH2:14])[C:8]=1[OH:17])(=[O:5])=[O:6])[CH3:2]

Participants

4

Reactant 2

HCID 18373485HCID 18373485, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373492HCID 18373492, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, crude N-ethyl-6-chloro-2-hydroxy-3-nitrobenzenesulfonamide (1.34 g) was reduced with hydrogen and 10% Pd/C (400 mg) to form the desired product (800 mg, 82% for two steps). 1H NMR (MeOD-d4): δ 6.85 (d, 1H), 6.78 (d, 1H), 2.85 (q, 2H), 0.95 (t, 3H).

Sources & evidence

ORD record
ord-2dd4586eea284f768ee59df9d2b88cb7
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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