Triethylamine → HCID 18345408, compound

HRID 2301617Notes

Reaction equation

HRID 2301617 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[CH2:16]([NH2:22])[C@@H:17]1[O:21][CH2:20][CH2:19][CH2:18]1.C(N(CC)CC)C>>[CH2:16]([NH:22][S:12]([C:3]1[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[Cl:1])(=[O:14])=[O:13])[C@@H:17]1[O:21][CH2:20][CH2:19][CH2:18]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 2734124(R)-(-)-TetrahydrofurfurylamineHCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 18345408HCID 18345408, compoundYield 97%

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (993 mg, 3.41 mmol), (2R)-tetrahydrofurfurylamine (0.36 mL, 3.49 mmol) and triethylamine(0.72 mL, 5.17 mmol) were reacted to form the desired product (1.17 g, 97%). EI-MS m/z 353(M-H)−.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-9a81ecbe1326498b8f91034728977149
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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