Water → HCID 54510442, compound

HRID 2301618Notes

Reaction equation

HRID 2301618 reaction equation
[CH2:1]([NH:7][S:8]([C:11]1[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([N+:18]([O-:20])=[O:19])[C:12]=1Cl)(=[O:10])=[O:9])[C@@H:2]1[O:6][CH2:5][CH2:4][CH2:3]1.[H-].[Na+].[OH2:24]>>[CH2:1]([NH:7][S:8]([C:11]1[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([N+:18]([O-:20])=[O:19])[C:12]=1[OH:24])(=[O:10])=[O:9])[C@@H:2]1[O:6][CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 18345408HCID 18345408, compound

Product 1

HCID 54510442HCID 54510442, compoundYield 63%

Procedure

Following the general hydrolysis procedure outlined in example 15, N-((2R)-tetrahydrofurfuryl)-2,6dichloro-3-nitrobenzenesulfonamide (1.17 g, 3.29 mmol), 80% NaH (303 mg, 10.1 mmol) and water (0.063 mL, 3.49 mmol) were reacted to form the desired product (690 mg, 63%). EI-MS m/z 335(M-H)−.

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-2fbb3b0eb37f4b5094c00c2807a6c004
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

Loading…