Triethylamine → HCID 69824390, compound

HRID 2301620Notes

Reaction equation

HRID 2301620 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[CH2:16]([NH2:22])[C@H:17]1[O:21][CH2:20][CH2:19][CH2:18]1.C(N(CC)CC)C>>[CH2:16]([NH:22][S:12]([C:3]1[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[Cl:1])(=[O:14])=[O:13])[C@H:17]1[O:21][CH2:20][CH2:19][CH2:18]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 641530(S)-(+)-TetrahydrofurfurylamineHCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 69824390HCID 69824390, compoundYield 99%

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (1.01 g, 3.44 mmol), (2S)-tetrahydrofurfurylamine (0.33 mL, 3.20 mmol) and triethylamine (0.72 mL, 5.17 mmol) were reacted to form the desired product (1.12 g, 99%). EI-MS m/z 353(M-H)−.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-52ff96c5a7c1440ab785c8fabce019f2
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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