Cyclopentylamine → HCID 18373500, compound

HRID 2301623Notes

Reaction equation

[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[C:3]=1[S:12](Cl)(=[O:14])=[O:13].[CH:16]1([NH2:21])[CH2:20][CH2:19][CH2:18][CH2:17]1.C(N(CC)CC)C>>[CH:16]1([NH:21][S:12]([C:3]2[C:4]([Cl:11])=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=2[Cl:1])(=[O:14])=[O:13])[CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

Reactant 3

HCID 2906Cyclopentylamine

HCID 8471Triethylamine

HCID 234477722,6-Dichloro-3-nitrobenzene-1-sulfonyl chloride

Product 1

HCID 18373500HCID 18373500, compoundYield 59%

Procedure

Following the general procedure for sulfonamide formation outlined in example 15, 2,6-dichloro-3-nitrobenzenesulfonyl chloride (1.6 g, 5.5 mmol), cyclopentylamine (0.54 mL, 5.5 mmol) and triethylamine (1.1 mL, 7.8 mmol) were reacted to form the desired product (1.1 g, 59%). LC-MS m/z 339(M+).

Workup

customwere reacted

Sources & evidence

ORD record: ord-a2f7762d3c0e4e0a9ec36fb8f6099a8c
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06500863B1

Reaction notes

Loading…