Water → HCID 86588376, compound

HRID 2301632Notes

Reaction equation

HRID 2301632 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][N:2]1[C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([S:13]([NH2:16])(=[O:15])=[O:14])=[C:8](Cl)[C:7]=1[N+:18]([O-:20])=[O:19].[H-].[Na+].[OH2:23]>>[O:1]1[CH2:5][CH2:4][CH2:3][N:2]1[C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([S:13]([NH2:16])(=[O:15])=[O:14])=[C:8]([OH:23])[C:7]=1[N+:18]([O-:20])=[O:19]

Participants

4

Reactant 3

HCID 962WaterHCID 24758Sodium hydrideHCID 86587417HCID 86587417, compound

Product 1

HCID 86588376HCID 86588376, compoundYield 53.3%

Procedure

Following the general hydrolysis procedure outlined in example 15, (N-tetrahydroisoxazyl)-2,6 -dichloro-3-nitrobenzenesulfonamide (0.1 g, 0.29 mmol), 80% NaH (26 mg, 0.88 mmol) and water (6.3 μL, 0.35 mmol) were reacted to form the desired product (50 mg, 53%). LC-MS m/z 323(M+).

Workup

  1. customthe general hydrolysis procedure
  2. customwere reacted

Sources & evidence

ORD record
ord-175e837c940c423eacf9290f6c067bbe
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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