HCID 18373434, compound → HCID 18373538, compound

HRID 2301645Notes

Reaction equation

HRID 2301645 reaction equation
[C:1]([NH:5][S:6]([C:9]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([N+:16]([O-])=O)[C:10]=1[OH:19])(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>[Pd]>[C:1]([NH:5][S:6]([C:9]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]([NH2:16])[C:10]=1[OH:19])(=[O:8])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 18373434HCID 18373434, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18373538HCID 18373538, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Following the general hydrogenation procedure outlined in example 15, crude N-(tert-butyl)6chloro-2-hydroxy-3-nitrobenzenesulfonamide (1 .54 g) was reduced with hydrogen and 10% Pd/C (670 mg). The crude product (1.23 g) was carried on to the next step without purification. 1H NMR (MeOD-d4): 8 6.82 (m, 2H), 1.22 (s, 9H).

Workup

  1. customThe crude product (1.23 g) was carried on to the next step without purification

Sources & evidence

ORD record
ord-31f9412e3adf4320ad0869145bef6d5d
Source dataset
uspto-grants-2002_12
Patent number
US06500863B1

Reaction notes

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