Trifluoroacetic acid → HCID 88011334, compound

HRID 2301651Notes

Reaction equation

C(OC([NH:8][CH2:9][CH2:10][NH:11][S:12]([C:15]1[C:16]([OH:34])=[C:17]([NH:22][C:23]([NH:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[C:27]=2[Cl:33])=[O:24])[CH:18]=[CH:19][C:20]=1[Cl:21])(=[O:14])=[O:13])=O)(C)(C)C.[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38]>>[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38].[NH2:8][CH2:9][CH2:10][NH:11][S:12]([C:15]1[C:16]([OH:34])=[C:17]([NH:22][C:23]([NH:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[C:27]=2[Cl:33])=[O:24])[CH:18]=[CH:19][C:20]=1[Cl:21])(=[O:14])=[O:13]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 54006149HCID 54006149, compound

Product 1

HCID 88011334HCID 88011334, compoundYield 100%

Procedure

Following the general procedure for Boc deprotection outlined in example 36, N-[3-[N″-[2-(tert-butoxycarbonylamino)ethyl]aminosulfonyl]4-chloro-2-hydroxyphenyl]-N′(2,3-dichlorophenyl) urea (56 mg, 0.10 mmol) was stirred in trifluoroacetic acid to form the desired product (57 mg, 100%). LC-MS (m/z) 453.0 (M+).

Sources & evidence

ORD record: ord-2365fde8e3034472a84712cf16c3140f
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06500863B1

Reaction notes

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