反应详情

A suspension of (1-ethyl-7-hydroxy-2-oxo-1,2-dihydro-quinolin-3-yl)-acetic acid (2.9 g, 12 mmol) in methanol (30 mL) was treated with 12 N aqueous HCl (3 mL, 36 mmol) and the mixture heated to reflux. After 5 h, the resulting solution was cooled to room temperature, filtered and left standing overnight. The resulting solid was vacuum filtered, washed with ice-cold methanol and air-dried to give the title compound (1.8 g, 58% yield) as white needles.

1. temperaturethe mixture heated to reflux
2. filtrationfiltered
3. waitleft
4. waitstanding overnight
5. filtrationfiltered
6. washwashed with ice-cold methanol
7. customair-dried