反应详情

A mixture of 2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol (21.85 g), sodium azide (10.7 g) and dimethyformamide (260 ml) is heated with stirring at 75°-80° C. overnight. After cooling, the mixture is treated with water, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from hexane to give 2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (19.6 g).

1. temperatureis heated
2. temperatureAfter cooling
3. extractionextracted with ethyl acetate
4. washThe ethyl acetate layer is washed
5. customdried
6. customevaporated
7. customto remove the solvent
8. customThe residue is crystallized from hexane