Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl 3-(2-chloro-6-methoxyquinolin-3-yl)prop-2-enoate | HCID 71360096 | — |
| Product | HCID 69979738 | HCID 69979738 | 95% |
Reaction Steps
A suspension of 3-(2-chloro-6-methoxy-quinolin-3-yl)-acrylic acid ethyl ester (20.2 g, 69.2 mmol) in ethanol (175 mL) was treated with 12 N aqueous HCl and heated to reflux to form a solution. After 21 h, the resulting precipitate was cooled to 0° C. for 1 h. Vacuum filtration gave the title compound (18.0 g, 95% yield) as a yellow crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06429214B1 |
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| Source dataset | uspto-grants-2002_08 |
|---|
| ORD ID | ord-72634867b9c4448b9ba0a3ade6a4e539 |
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| Source note | uspto-grants-2002_08 |
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