Hydrochloric Acid → HCID 69979738, compound

HRID 2302012Notes

Reaction equation

HRID 2302012 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[CH:5]=[CH:6][C:7]1[C:8](Cl)=[N:9][C:10]2[C:15]([CH:16]=1)=[CH:14][C:13]([O:17][CH3:18])=[CH:12][CH:11]=2)[CH3:2].Cl.C([OH:24])C>>[CH2:1]([O:3][C:4](=[O:20])[CH:5]=[CH:6][C:7]1[C:8](=[O:24])[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][C:13]([O:17][CH3:18])=[CH:12][CH:11]=2)[CH3:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 71360096Ethyl 3-(2-chloro-6-methoxyquinolin-3-yl)prop-2-enoate

Product 1

HCID 69979738HCID 69979738, compoundYield 95%

Conditions

Temperature
0 °C

Procedure

A suspension of 3-(2-chloro-6-methoxy-quinolin-3-yl)-acrylic acid ethyl ester (20.2 g, 69.2 mmol) in ethanol (175 mL) was treated with 12 N aqueous HCl and heated to reflux to form a solution. After 21 h, the resulting precipitate was cooled to 0° C. for 1 h. Vacuum filtration gave the title compound (18.0 g, 95% yield) as a yellow crystalline solid.

Workup

  1. temperatureheated
  2. temperatureto reflux
  3. customto form a solution
  4. filtrationVacuum filtration

Sources & evidence

ORD record
ord-72634867b9c4448b9ba0a3ade6a4e539
Source dataset
uspto-grants-2002_08
Patent number
US06429214B1

Reaction notes

Loading…